Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …

Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …

BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …

Though the acute effects of SARS-CoV-2 infection have been extensively reported, the long-
term effects are less well described. Specifically, while clinicians endure to battle COVID-19 …

The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It is
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high …

Organoids and organs-on-chips are two rapidly emerging 3D cell culture techniques that
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …

Despite tremendous progress in the development of mature heart-on-a-chip models, human
cell–based models of myocardial inflammation are lacking. Here, we bioengineered a …

The in vitro oxygen microenvironment profoundly affects the capacity of cell cultures to
model physiological and pathophysiological states. Cell culture is often considered to be …

Abstracts The coronavirus disease 2019 (COVID-19) affects infected patients even after the
acute phase and impairs their health and quality of life by causing a wide variety of …