Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections
U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …
and artificial intelligence provide new opportunities for target-based antibacterial drug …
The impact of structural genomics: expectations and outcomes
JM Chandonia, SE Brenner - science, 2006 - science.org
Structural genomics (SG) projects aim to expand our structural knowledge of biological
macromolecules while lowering the average costs of structure determination. We …
macromolecules while lowering the average costs of structure determination. We …
JPred4: a protein secondary structure prediction server
Abstract JPred4 (http://www. compbio. dundee. ac. uk/jpred4) is the latest version of the
popular JPred protein secondary structure prediction server which provides predictions by …
popular JPred protein secondary structure prediction server which provides predictions by …
Prediction of protein solubility based on sequence physicochemical patterns and distributed representation information with DeepSoluE
Background Protein solubility is a precondition for efficient heterologous protein expression
at the basis of most industrial applications and for functional interpretation in basic research …
at the basis of most industrial applications and for functional interpretation in basic research …
The Jpred 3 secondary structure prediction server
Abstract Jpred (http://www. compbio. dundee. ac. uk/jpred) is a secondary structure
prediction server powered by the Jnet algorithm. Jpred performs over 1000 predictions per …
prediction server powered by the Jnet algorithm. Jpred performs over 1000 predictions per …
SOLpro: accurate sequence-based prediction of protein solubility
Motivation: Protein insolubility is a major obstacle for many experimental studies. A
sequence-based prediction method able to accurately predict the propensity of a protein to …
sequence-based prediction method able to accurately predict the propensity of a protein to …
Evaluating protein structures determined by structural genomics consortia
A Bhattacharya, R Tejero… - … : Structure, Function, and …, 2007 - Wiley Online Library
Structural genomics projects are providing large quantities of new 3D structural data for
proteins. To monitor the quality of these data, we have developed the protein structure …
proteins. To monitor the quality of these data, we have developed the protein structure …
The RCSB PDB information portal for structural genomics
A Kouranov, L **e, J de la Cruz, L Chen… - Nucleic acids …, 2006 - academic.oup.com
Abstract The RCSB Protein Data Bank (PDB) offers online tools, summary reports and target
information related to the worldwide structural genomics initiatives from its portal at http://sg …
information related to the worldwide structural genomics initiatives from its portal at http://sg …
XtalPred: a web server for prediction of protein crystallizability
L Slabinski, L Jaroszewski, L Rychlewski… - …, 2007 - academic.oup.com
XtalPred is a web server for prediction of protein crystallizability. The prediction is made by
comparing several features of the protein with distributions of these features in TargetDB …
comparing several features of the protein with distributions of these features in TargetDB …
PROSO II–a new method for protein solubility prediction
Many fields of science and industry depend on efficient production of active protein using
heterologous expression in Escherichia coli. The solubility of proteins upon expression is …
heterologous expression in Escherichia coli. The solubility of proteins upon expression is …