Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections

U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

The impact of structural genomics: expectations and outcomes

JM Chandonia, SE Brenner - science, 2006 - science.org
Structural genomics (SG) projects aim to expand our structural knowledge of biological
macromolecules while lowering the average costs of structure determination. We …

JPred4: a protein secondary structure prediction server

A Drozdetskiy, C Cole, J Procter… - Nucleic acids …, 2015 - academic.oup.com
Abstract JPred4 (http://www. compbio. dundee. ac. uk/jpred4) is the latest version of the
popular JPred protein secondary structure prediction server which provides predictions by …

Prediction of protein solubility based on sequence physicochemical patterns and distributed representation information with DeepSoluE

C Wang, Q Zou - BMC biology, 2023 - Springer
Background Protein solubility is a precondition for efficient heterologous protein expression
at the basis of most industrial applications and for functional interpretation in basic research …

The Jpred 3 secondary structure prediction server

C Cole, JD Barber, GJ Barton - Nucleic acids research, 2008 - academic.oup.com
Abstract Jpred (http://www. compbio. dundee. ac. uk/jpred) is a secondary structure
prediction server powered by the Jnet algorithm. Jpred performs over 1000 predictions per …

SOLpro: accurate sequence-based prediction of protein solubility

CN Magnan, A Randall, P Baldi - Bioinformatics, 2009 - academic.oup.com
Motivation: Protein insolubility is a major obstacle for many experimental studies. A
sequence-based prediction method able to accurately predict the propensity of a protein to …

Evaluating protein structures determined by structural genomics consortia

A Bhattacharya, R Tejero… - … : Structure, Function, and …, 2007 - Wiley Online Library
Structural genomics projects are providing large quantities of new 3D structural data for
proteins. To monitor the quality of these data, we have developed the protein structure …

The RCSB PDB information portal for structural genomics

A Kouranov, L **e, J de la Cruz, L Chen… - Nucleic acids …, 2006 - academic.oup.com
Abstract The RCSB Protein Data Bank (PDB) offers online tools, summary reports and target
information related to the worldwide structural genomics initiatives from its portal at http://sg …

XtalPred: a web server for prediction of protein crystallizability

L Slabinski, L Jaroszewski, L Rychlewski… - …, 2007 - academic.oup.com
XtalPred is a web server for prediction of protein crystallizability. The prediction is made by
comparing several features of the protein with distributions of these features in TargetDB …

PROSO II–a new method for protein solubility prediction

P Smialowski, G Doose, P Torkler… - The FEBS …, 2012 - Wiley Online Library
Many fields of science and industry depend on efficient production of active protein using
heterologous expression in Escherichia coli. The solubility of proteins upon expression is …