Inductively coupled plasma mass spectrometry (ICP-MS) combines plasma chemistry, which
produces singly charged elemental ions, with mass spectrometric detection. Unlike other …

Elemental imaging gives insight into the fundamental chemical makeup of living organisms.
Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements …

Mass cytometry enables high-dimensional, single-cell analysis of cell type and state. In
mass cytometry, rare earth metals are used as reporters on antibodies. Analysis of metal …

Single-cell, spatially resolved omics analysis of tissues is poised to transform biomedical
research and clinical practice. We have developed an open-source, computational histology …

Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

This tutorial review focuses on the use of ICP-MS based techniques for the analysis of metal-
containing nanoparticles and colloids. Within the first part the capabilities of “stand alone” …

Tumours vary in gene expression programmes and genetic alterations. Understanding this
diversity and its biological meaning requires a theoretical framework, which could in turn …

Increasing evidence suggests that the spatial distribution of biomolecules within cells is a
critical component in deciphering single-cell molecular heterogeneity. State-of-the-art single …

Over the last two decades, mass spectrometry imaging (MSI) has been increasingly
employed to investigate the spatial distribution of a wide variety of molecules in complex …

The study of organs and tissues on a molecular level is necessary as we seek an
understanding of health and disease. Over the last few years, powerful highly multiplexed …