[HTML][HTML] Essential metals in health and disease
In total, twenty elements appear to be essential for the correct functioning of the human
body, half of which are metals and half are non-metals. Among those metals that are …
body, half of which are metals and half are non-metals. Among those metals that are …
[HTML][HTML] The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species
Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …
Copper induces cell death by targeting lipoylated TCA cycle proteins
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …
A polymeric hydrogel to eliminate programmed death-ligand 1 for enhanced tumor radio-immunotherapy
Programmed death-ligand 1 (PD-L1) is a specialized shield on tumor cells that evades the
immune system. Even inhibited by PD-L1 antibodies, a cycling process constantly transports …
immune system. Even inhibited by PD-L1 antibodies, a cycling process constantly transports …
Cuproptosis: Harnessing transition metal for cancer therapy
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
The bioinorganic chemistry of mammalian metallothioneins
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …
speculations since the discovery of the protein over 60 years ago. This article guides …
Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A
Cancer cells reprogram their copper metabolism to adapt to adverse microenvironments,
such as oxidative stress. The copper chelator elesclomol has been reported to have …
such as oxidative stress. The copper chelator elesclomol has been reported to have …
Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy
Nanoformulations that can respond to the specific tumor microenvironment (TME), such as a
weakly acidic pH, low oxygen, and high glutathione (GSH), show promise for killing cancer …
weakly acidic pH, low oxygen, and high glutathione (GSH), show promise for killing cancer …
Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies
X Wang, M Zhou, Y Liu, Z Si - Cancer Letters, 2023 - Elsevier
Recent studies have established a strong link between copper and cancer biology, as
copper is necessary for cancer growth and metastasis. Beyond the conventional concept of …
copper is necessary for cancer growth and metastasis. Beyond the conventional concept of …
System analysis based on the cuproptosis-related genes identifies LIPT1 as a novel therapy target for liver hepatocellular carcinoma
C Yan, Y Niu, L Ma, L Tian, J Ma - Journal of Translational Medicine, 2022 - Springer
Background Liver hepatocellular carcinoma (LIHC) ranks sixth among the most common
types of cancer with a high mortality rate. Cuproptosis is a newly discovered type of cell …
types of cancer with a high mortality rate. Cuproptosis is a newly discovered type of cell …