Anti-tuberculosis treatment strategies and drug development: challenges and priorities
VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …
biological uncertainties remain and hamper progress. However, owing to collaborative …
New developments in tuberculosis diagnosis and treatment
CM Gill, L Dolan, LM Piggott, AM McLaughlin - Breathe, 2022 - Eur Respiratory Soc
Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. It is estimated that
25% of the world's population are infected with Mycobacterium tuberculosis, with a 5–10 …
25% of the world's population are infected with Mycobacterium tuberculosis, with a 5–10 …
[HTML][HTML] The role of IGRA in the diagnosis of tuberculosis infection, differentiating from active tuberculosis, and decision making for initiating treatment or preventive …
ABSTRACT Objectives The World Health Organization estimated that a quarter of the global
population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis …
population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis …
[HTML][HTML] The definition of tuberculosis infection based on the spectrum of tuberculosis disease
GB Migliori, CWM Ong, L Petrone, L D'Ambrosio… - Breathe, 2021 - Eur Respiratory Soc
Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB)
infection. This term was used to define “a state of persistent immune response to stimulation …
infection. This term was used to define “a state of persistent immune response to stimulation …
Diagnostic biomarkers for active tuberculosis: progress and challenges
BMF Nogueira, S Krishnan… - EMBO Molecular …, 2022 - embopress.org
Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious
agent, despite being preventable and curable. Early and accurate diagnosis of active TB is …
agent, despite being preventable and curable. Early and accurate diagnosis of active TB is …
Clinical standards for the diagnosis, treatment and prevention of TB infection
GB Migliori, SJ Wu, A Matteelli, D Zenner… - … of Tuberculosis and …, 2022 - ingentaconnect.com
BACKGROUND: Tuberculosis (TB) preventive therapy (TPT) decreases the risk of
develo** TB disease and its associated morbidity and mortality. The aim of these clinical …
develo** TB disease and its associated morbidity and mortality. The aim of these clinical …
Tuberculosis treatment monitoring and outcome measures: new interest and new strategies
Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …
global public health threat. A significant challenge for TB control efforts has been the …
[HTML][HTML] Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis
Blood transcriptomics have revealed major characteristics of the immune response in active
TB, but the signature early after infection is unknown. In a unique clinically and temporally …
TB, but the signature early after infection is unknown. In a unique clinically and temporally …
A half-century of research on tuberculosis: Successes and challenges
BR Bloom - Journal of Experimental Medicine, 2023 - rupress.org
Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …
global health problem, particularly in low-and middle-income countries. Understanding the …
Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?
Rapid, accurate, sputum-free tests for tuberculosis (TB) triage and confirmation are urgently
needed to close the widening diagnostic gap. We summarise key technologies and review …
needed to close the widening diagnostic gap. We summarise key technologies and review …