Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound

Z Xu, TL Hall, E Vlaisavljevich… - International Journal of …, 2021‏ - Taylor & Francis
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology
guided by real-time imaging. Using focused ultrasound delivered from outside the body …

Histotripsy: a method for mechanical tissue ablation with ultrasound

Z Xu, TD Khokhlova, CS Cho… - Annual Review of …, 2024‏ - annualreviews.org
Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy
tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to …

[HTML][HTML] For whom the bubble grows: physical principles of bubble nucleation and dynamics in histotripsy ultrasound therapy

KB Bader, E Vlaisavljevich, AD Maxwell - Ultrasound in medicine & biology, 2019‏ - Elsevier
Histotripsy is a focused ultrasound therapy for non-invasive tissue ablation. Unlike thermally
ablative forms of therapeutic ultrasound, histotripsy relies on the mechanical action of …

[HTML][HTML] Applications of focused ultrasound for the treatment of glioblastoma: a new frontier

AM Hersh, M Bhimreddy, C Weber-Levine, K Jiang… - Cancers, 2022‏ - mdpi.com
Simple Summary Glioblastoma (GBM) is a common primary brain tumor with a short median
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …

Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy

S Qu, T Worlikar, AE Felsted, A Ganguly… - Journal for …, 2020‏ - pmc.ncbi.nlm.nih.gov
Background Develo** the ability to use tumor-directed therapies to trigger potentially
therapeutic immune responses against cancer antigens remains a high priority for cancer …

Cavitation clouds created by shock scattering from bubbles during histotripsy

AD Maxwell, TY Wang, CA Cain, JB Fowlkes… - The Journal of the …, 2011‏ - pubs.aip.org
Histotripsy is a therapy that focuses short-duration, high-amplitude pulses of ultrasound to
incite a localized cavitation cloud that mechanically breaks down tissue. To investigate the …

Probability of cavitation for single ultrasound pulses applied to tissues and tissue-mimicking materials

AD Maxwell, CA Cain, TL Hall, JB Fowlkes… - Ultrasound in medicine & …, 2013‏ - Elsevier
In this study, the negative pressure values at which inertial cavitation consistently occurs in
response to a single, two-cycle, focused ultrasound pulse were measured in several media …

Role of acoustic cavitation in the delivery and monitoring of cancer treatment by high-intensity focused ultrasound (HIFU)

CC Coussios, CH Farny, G Ter Haar… - International journal of …, 2007‏ - Taylor & Francis
Acoustic cavitation has been shown to play a key role in a wide array of novel therapeutic
ultrasound applications. This paper presents a brief discussion of the physics of thermally …

Focused ultrasound surgery in oncology: overview and principles

CMC Tempany, NJ McDannold, K Hynynen, FA Jolesz - Radiology, 2011‏ - pubs.rsna.org
Focused ultrasound surgery (FUS) is a noninvasive image-guided therapy and an
alternative to surgical interventions. It presents an opportunity to revolutionize cancer …

Carbon-nanotube optoacoustic lens for focused ultrasound generation and high-precision targeted therapy

HW Baac, JG Ok, A Maxwell, KT Lee, YC Chen… - Scientific reports, 2012‏ - nature.com
We demonstrate a new optical approach to generate high-frequency (> 15 MHz) and high-
amplitude focused ultrasound, which can be used for non-invasive ultrasound therapy. A …