Background: Inherited and sporadic medullary thyroid cancer (MTC) is an uncommon and
challenging malignancy. The American Thyroid association (ATA) chose to create specific …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

MULTIPLE endocrine neoplasia type 2 (MEN 2) comprises three clinically distinct,
dominantly inherited cancer syndromes. MEN 2A patients develop medullary thyroid …

The antioncogenes, or tumor suppressor genes, as negative regulators of cell division, stand
in contrast to oncogenes. For most human cancers, the more frequently mutated genes are …

Segregation analysis of breast cancer in families can provide the logical basis and the
specific genetic models for map** and identifying genes responsible for human breast …

Multiple endocrine neoplasia type 2B (MEN 2B) is a human cancer syndrome characterized
by medullary thyroid carcinoma (MTC), pheochromocytomas, mucosal neuromas …

A novel polymerase chain reaction (PCR) technique has been combined with chromosome
flow sorting to characterise two lymphoblastoid cell lines and one medullary thyroid …

We report the construction of a linkage map of the human genome, based on the pattern of
inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three …

The RET gene encodes a receptor tyrosine kinase that is expressed in neural crest-derived
cell lineages. The RET receptor plays a crucial role in regulating cell proliferation, migration …

The history of tyrosine kinase oncogenes can be traced to 1911 when Peyton Rous, of the
Rockefeller Institute, demonstrated that a chicken tumor could be wx transplanted using a …