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Structure and mechanism of the pepsin-like family of aspartic peptidases
BM Dunn - Chemical reviews, 2002 - ACS Publications
The last general review of the aspartic peptidase family was by David R. Davies in 1990. 1
Since then, several reviews on selected aspects of the structure and function of aspartic …
Since then, several reviews on selected aspects of the structure and function of aspartic …
Nerve growth factor mediates signal transduction through trk homodimer receptors
We have investigated the molecular nature of the high affinity nerve growth factor (NGF)
receptors by using cell lines expressing gp75 LNGFR and gp140 trk Our results suggest that …
receptors by using cell lines expressing gp75 LNGFR and gp140 trk Our results suggest that …
Multifunctional aspartic peptidase prosegments
The structure–function relationships of aspartic peptidases (APs)(EC 3.4. 23. X) have been
extensively investigated, yet much remains to be elucidated regarding the various molecular …
extensively investigated, yet much remains to be elucidated regarding the various molecular …
The clinical potential of renin inhibitors and angiotensin antagonists
RJ Cody - Drugs, 1994 - Springer
The renin angiotensin system is a major contributor to the pathophysiology of cardiovascular
diseases such as congestive heart failure and hypertension. For this reason, attempts to …
diseases such as congestive heart failure and hypertension. For this reason, attempts to …
Prosegment catalyzes pepsin folding to a kinetically trapped native state
Pepsin, an archetypical aspartic peptidase, initially contains an N-terminal, 44 residue
prosegment (PS) that, upon folding, is removed to yield native pepsin (Np). Np is irreversibly …
prosegment (PS) that, upon folding, is removed to yield native pepsin (Np). Np is irreversibly …
The Propeptide Is Nonessential for the Expression of Human Cathepsin D (∗)
SC Fortenberry, JM Chirgwin - Journal of Biological Chemistry, 1995 - jbc.org
When the 44-amino acid propeptide of human procathepsin D was deleted by mutagenesis
in vitro, the mature protein was stably expressed and secreted from transfected mammalian …
in vitro, the mature protein was stably expressed and secreted from transfected mammalian …
Scaled-up production of recombinant human renin in CHO cells for enzymatic and X-ray structure analysis
FAM Asselbergs, J Rahuel, F Cumin, C Leist - Journal of biotechnology, 1994 - Elsevier
A process was developed to produce recombinant human renin for X-ray analysis and
enzyme inhibition studies. An expression vector containing a human prorenin cDNA and …
enzyme inhibition studies. An expression vector containing a human prorenin cDNA and …
The prosegment catalyzes native folding of Plasmodium falciparum plasmepsin II
Plasmepsin II is a malarial pepsin-like aspartic protease produced as a zymogen containing
an N-terminal prosegment domain that is removed during activation. Despite structural …
an N-terminal prosegment domain that is removed during activation. Despite structural …
Foldase and inhibitor functionalities of the pepsinogen prosegment are encoded within discrete segments of the 44 residue domain
Pepsin is initially produced as the zymogen pepsinogen, containing a 44 residue
prosegment (PS) domain. When folded without the PS, pepsin forms a thermodynamically …
prosegment (PS) domain. When folded without the PS, pepsin forms a thermodynamically …
Development of novel renin inhibitors and interaction of antimicrobial and cytotoxic peptides with plasma proteins. A drug discovery study
A Sivertsen - 2013 - munin.uit.no
In this study we have explored the structure activity relationship of molecules with potential
as novel drug classes toward current medical challenges as hypertension, cancer and …
as novel drug classes toward current medical challenges as hypertension, cancer and …