Genetics of diabetes mellitus and diabetes complications
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
Albumin uptake and processing by the proximal tubule: Physiological, pathological, and therapeutic implications
BA Molitoris, RM Sandoval, SPS Yadav… - Physiological …, 2022 - journals.physiology.org
For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …
Genome-wide polygenic score to predict chronic kidney disease across ancestries
Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …
Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
Causal effects of specific gut microbiota on chronic kidney diseases and renal function—a two-sample Mendelian randomization study
Background: Targeting the gut microbiota may become a new therapeutic to prevent and
delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship …
delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship …
Map** the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
The functional interpretation of genome-wide association studies (GWAS) is challenging due
to the cell-type-dependent influences of genetic variants. Here, we generated …
to the cell-type-dependent influences of genetic variants. Here, we generated …
White blood cells and blood pressure: a Mendelian randomization study
M Siedlinski, E Jozefczuk, X Xu, A Teumer… - Circulation, 2020 - Am Heart Assoc
Background: High blood pressure (BP) is a risk factor for cardiovascular morbidity and
mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic …
mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic …
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological …
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
People with kidney disease are disproportionately affected by atherosclerosis for unclear
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …
reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived …
Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function
Kidney failure, the decrease of kidney function below a threshold necessary to support life, is
a major cause of morbidity and mortality. We performed a genome-wide association study …
a major cause of morbidity and mortality. We performed a genome-wide association study …