[HTML][HTML] DNA methylation: a historical perspective
In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …
been extensively researched since the landmark report by Morpurgo (1897) of “work …
OrthoVenn3: an integrated platform for exploring and visualizing orthologous data across genomes
Advancements in comparative genomics research have led to a growing interest in studying
species evolution and genetic diversity. To facilitate this research, OrthoVenn3 has been …
species evolution and genetic diversity. To facilitate this research, OrthoVenn3 has been …
A complete telomere-to-telomere assembly of the maize genome
J Chen, Z Wang, K Tan, W Huang, J Shi, T Li, J Hu… - Nature …, 2023 - nature.com
A complete telomere-to-telomere (T2T) finished genome has been the long pursuit of
genomic research. Through generating deep coverage ultralong Oxford Nanopore …
genomic research. Through generating deep coverage ultralong Oxford Nanopore …
DNABERT: pre-trained Bidirectional Encoder Representations from Transformers model for DNA-language in genome
Motivation Deciphering the language of non-coding DNA is one of the fundamental
problems in genome research. Gene regulatory code is highly complex due to the existence …
problems in genome research. Gene regulatory code is highly complex due to the existence …
Towards complete and error-free genome assemblies of all vertebrate species
High-quality and complete reference genome assemblies are fundamental for the
application of genomics to biology, disease, and biodiversity conservation. However, such …
application of genomics to biology, disease, and biodiversity conservation. However, such …
DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
Transcription of MERVL retrotransposons is required for preimplantation embryo development
Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency
and allows different cell fates to emerge in the develo** embryo. MERVL (murine …
and allows different cell fates to emerge in the develo** embryo. MERVL (murine …
Transposable elements shape the evolution of mammalian development
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
Despite multiple layers of host defence, TEs actively shape mammalian-specific …
CAFE 5 models variation in evolutionary rates among gene families
Motivation Genome sequencing projects have revealed frequent gains and losses of genes
between species. Previous versions of our software, Computational Analysis of gene Family …
between species. Previous versions of our software, Computational Analysis of gene Family …