Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
The impact of DNA methylation on CTCF-mediated 3D genome organization
Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although
the role of DNA methylation at gene promoters and repetitive elements has been extensively …
the role of DNA methylation at gene promoters and repetitive elements has been extensively …
DNA methylation in mammalian development and disease
The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …
characterization to one seeking deeper functional understanding of how this modification …
Mechanical regulation of chromatin and transcription
Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
Understanding 3D genome organization by multidisciplinary methods
Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …
function. Although 3D genome organization has been historically difficult to study owing to a …
Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
3D genomics across the tree of life reveals condensin II as a determinant of architecture type
C Hoencamp, O Dudchenko, AMO Elbatsh… - Science, 2021 - science.org
We investigated genome folding across the eukaryotic tree of life. We find two types of three-
dimensional (3D) genome architectures at the chromosome scale. Each type appears and …
dimensional (3D) genome architectures at the chromosome scale. Each type appears and …
Computational methods for analysing multiscale 3D genome organization
Recent progress in whole-genome map** and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …
characterization of the spatial organization and folding of the genome in the nucleus. In …
The role of 3D genome organization in development and cell differentiation
H Zheng, W ** 3D chromosome architecture
R Kempfer, A Pombo - Nature Reviews Genetics, 2020 - nature.com
Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …
understanding the role of chromatin topology in gene regulation. Several methods are …