Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

Background Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction,
characterized by cognitive and memory impairments closely linked to hippocampal …

The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

Abstract Background In Alzheimer's disease (AD), the associations between tau pathology
and brain atrophy and cognitive decline are well established, but imperfect. We investigate …

As the global population ages, the need to prolong lifespan and healthspan becomes
increasingly imperative. Understanding the molecular determinants underlying cognitive …

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor …

Neuroinflammation is an inflammatory cascade involved in various neurological disorders,
including Alzheimer's disease, multiple sclerosis, and other relevant diseases. The …