The many functions of ESCRTs

M Vietri, M Radulovic, H Stenmark - Nature reviews Molecular cell …, 2020 - nature.com
Cellular membranes can form two principally different involutions, which either exclude or
contain cytosol. The 'classical'budding reactions, such as those occurring during …

Cellular functions and molecular mechanisms of the ESCRT membrane-scission machinery

L Christ, C Raiborg, EM Wenzel, C Campsteijn… - Trends in biochemical …, 2017 - cell.com
The endosomal sorting complex required for transport (ESCRT) machinery is an assembly of
protein subcomplexes (ESCRT I-III) that cooperate with the ATPase VPS4 to mediate …

A fluorescent membrane tension probe

A Colom, E Derivery, S Soleimanpour, C Tomba… - Nature …, 2018 - nature.com
Cells and organelles are delimited by lipid bilayers in which high deformability is essential to
many cell processes, including motility, endocytosis and cell division. Membrane tension is …

Membrane and organelle dynamics during cell division

JG Carlton, H Jones, US Eggert - Nature Reviews Molecular Cell …, 2020 - nature.com
During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …

Cytokinetic abscission: molecular mechanisms and temporal control

B Mierzwa, DW Gerlich - Developmental cell, 2014 - cell.com
Cytokinesis mediates the physical separation of dividing cells after chromosome
segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and …

[HTML][HTML] Dividing cells regulate their lipid composition and localization

GE Atilla-Gokcumen, E Muro, J Relat-Goberna… - Cell, 2014 - cell.com
Although massive membrane rearrangements occur during cell division, little is known about
specific roles that lipids might play in this process. We report that the lipidome changes with …

Membrane tension and cytoskeleton organization in cell motility

P Sens, J Plastino - Journal of Physics: Condensed Matter, 2015 - iopscience.iop.org
Cell membrane shape changes are important for many aspects of normal biological function,
such as tissue development, wound healing and cell division and motility. Various disease …

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

BE Mierzwa, N Chiaruttini, L Redondo-Morata… - Nature cell …, 2017 - nature.com
The endosomal sorting complex required for transport (ESCRT)-III mediates membrane
fission in fundamental cellular processes, including cytokinesis. ESCRT-III is thought to form …

Enzyme‐Instructed Self‐Assembly Enabled Monomer–Excimer Transition to Construct Higher Ordered Luminescent Supramolecular Assembly for Activity‐based …

Y Zhong, J Zhan, G Xu, Y Chen, Q Qin… - Angewandte Chemie …, 2021 - Wiley Online Library
It is challenging to construct high‐performing excimer‐based luminescent analytic tools at
low molecular concentrations. We report that enzyme‐instructed self‐assembly (EISA) …

Mechanical stress driven by rigidity sensing governs epithelial stability

S Sonam, L Balasubramaniam, SZ Lin, YMY Ivan… - Nature physics, 2023 - nature.com
Epithelia act as barriers against environmental stresses. They are continuously exposed to
various mechanical stress and abrasion, which impact epithelial integrity. The impact of the …