Matrix stiffness is a mechanical characteristic of the extracellular matrix (ECM) that increases
from the tumor core to the tumor periphery in a gradient pattern in a variety of solid tumors …

Background Cell stiffness is a crucial mechanical property that is closely related to cell
motility. AFM is the most prevalent method used to determine cell stiffness by the quantitative …

Biophysical cues of rigid tumor matrix play a critical role in cancer cell malignancy. We report
that stiffly confined cancer cells exhibit robust growth of spheroids in the stiff hydrogel that …

The tumour microenvironment contributes greatly to the response of tumour cells. It consists
of chemical gradients, for example of oxygen and nutrients. However, a physical …

From the first experiments of the atomic force microscopy (AFM) with biological samples, the
range of its potential applications grows extensively. One of them is the use of AFM to …

The deformability of a cell is the direct result of a complex interplay between the different
constituent elements at the subcellular level, coupling a wide range of mechanical …

In recent years, a growing consensus is emerging that the mechanical microenvironment of
tumors is far more critical in the onset of tumor, tumor progression, invasion, and metastasis …

The goal of this study was to understand if exosomes derived from high-metastatic cells may
influence the behavior of less aggressive cancer cells and the properties of the endothelium …

Glioblastoma (GBM) and meningothelial meningioma (MM) are the most frequent malignant
and benign brain lesions, respectively. Mechanical cues play a major role in the progression …

MicroRNAs (miRNAs) have a critical role in tumorigenesis and metastasis, which are major
obstacles of cancer therapy. However, the role of miRNAs in colorectal cancer (CRC) …