Melanocytic nevi and melanoma: unraveling a complex relationship
WE Damsky, M Bosenberg - Oncogene, 2017 - nature.com
Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …
Genetics of melanocytic nevi
Melanocytic nevi are a benign clonal proliferation of cells expressing the melanocytic
phenotype, with heterogeneous clinical and molecular characteristics. In this review, we …
phenotype, with heterogeneous clinical and molecular characteristics. In this review, we …
The paradox of cancer genes in non-malignant conditions: implications for precision medicine
Next-generation sequencing has enabled patient selection for targeted drugs, some of
which have shown remarkable efficacy in cancers that have the cognate molecular …
which have shown remarkable efficacy in cancers that have the cognate molecular …
Melanoma: genetic abnormalities, tumor progression, clonal evolution and tumor initiating cells
Melanoma is an aggressive neoplasia issued from the malignant transformation of
melanocytes, the pigment-generating cells of the skin. It is responsible for about 75% of …
melanocytes, the pigment-generating cells of the skin. It is responsible for about 75% of …
Cutaneous adverse events in patients treated with BRAF inhibitor‐based therapies for metastatic melanoma for longer than 52 weeks
R Anforth, G Carlos, A Clements… - British Journal of …, 2015 - academic.oup.com
Background BRAF inhibitor‐based therapies have been shown to induce cutaneous
toxicities, with onset generally in the first 8–26 weeks of therapy. Objectives To determine …
toxicities, with onset generally in the first 8–26 weeks of therapy. Objectives To determine …
RAMAN spectroscopy imaging improves the diagnosis of papillary thyroid carcinoma
Recent investigations strongly suggest that Raman spectroscopy (RS) can be used as a
clinical tool in cancer diagnosis to improve diagnostic accuracy. In this study, we evaluated …
clinical tool in cancer diagnosis to improve diagnostic accuracy. In this study, we evaluated …
Melanocytic naevi with globular and reticular dermoscopic patterns display distinct BRAF V600E expression profiles and histopathological patterns
Background BRAF (v‐raf murine sarcoma viral oncogene homologue B) V600E mutations
have been detected with high frequency in melanocytic naevi. Few studies have stratified …
have been detected with high frequency in melanocytic naevi. Few studies have stratified …
[HTML][HTML] Sequential digital dermatoscopic imaging of patients with multiple atypical nevi
P Tschandl - Dermatology practical & conceptual, 2018 - ncbi.nlm.nih.gov
Patients with multiple atypical nevi are at higher risk of develo** melanoma. Among
different techniques, sequential digital dermatoscopic imaging (SDDI) is a state-of-the art …
different techniques, sequential digital dermatoscopic imaging (SDDI) is a state-of-the art …
Dermoscopy in the era of dermato-oncology: from bed to bench side and retour
N Woltsche, C Schwab, T Deinlein… - Expert Review of …, 2016 - Taylor & Francis
Today dermoscopy is standard-of-care in the diagnosis and management of patients with
benign and malignant skin tumors because it increases the diagnostic accuracy of skin …
benign and malignant skin tumors because it increases the diagnostic accuracy of skin …
Evolution of melanocytic nevi under vemurafenib, followed by combination therapy with dabrafenib and trametinib for metastatic melanoma
C Giurcaneanu, C Nitipir, L Gabriela Popa… - Acta …, 2015 - hrcak.srce.hr
Treatment of advanced melanoma with selective BRAF and MEK inhibitors is associated
with a series of mucocutaneous side effects, among which morphological changes in …
with a series of mucocutaneous side effects, among which morphological changes in …