Emerging Therapeutics targeting cellular stress pathways to mitigate end-organ damage in type 1 diabetes

TA Addissouky - Avicenna Journal of Medical Biochemistry, 2024 - ajmb.umsha.ac.ir
Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by insulin
deficiency and impaired glucose regulation. While daily insulin therapy is life-saving, many …

[HTML][HTML] Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes

M Fogarasi, S Dima - Cells, 2024 - mdpi.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF protein superfamily and was initially identified as a protein capable of inducing …

Clinical importance of cytokine (IL-6, IL-8, and IL-10) and vitamin D levels among patients with Type-1 diabetes

AS Syed Khaja, NK Binsaleh, MMA Beg, F Ashfaq… - Scientific Reports, 2024 - nature.com
Abstract Type-1 diabetes (T1D) is an autoimmune disorder characterized by impaired insulin
release by islet β cells. It has been shown that proinflammatory cytokines released during …

Endowing polyetheretherketone with anti‐infection and immunomodulatory properties through guanidination carbon dots modification to promote osseointegration in …

X Bai, X Zhang, J **ao, X Lin, R Lin… - Advanced …, 2024 - Wiley Online Library
Methicillin‐resistant Staphylococcus aureus (MRSA) infection and compromised immunity
are the severe complications associated with implantation surgery in diabetes mellitus …

The Impact of Metabolic Memory on Immune Profile in Young Patients with Uncomplicated Type 1 Diabetes

J Neubauer-Geryk, M Wielicka, M Myśliwiec… - International Journal of …, 2024 - mdpi.com
Metabolic memory refers to the long-term effects of achieving early glycemic control and the
adverse implications of high blood glucose levels, including the development and …

[HTML][HTML] Evaluation of miRNA-146a, miRNA-34a, and pro-inflammatory cytokines as a potential early indicators for type 1 diabetes mellitus

AA Mohamed, GM Abdallah, IT Ibrahim, NS Ali… - Non-coding RNA …, 2024 - Elsevier
Background Type I diabetes mellitus (T1DM) is one of the most common chronic
autoimmune diseases worldwide. miRNAs are a class of small non-coding RNA molecules …

From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes

A Azad, HA Altunbas, AE Manguoglu - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction Type 1 diabetes (T1D) mellitus is an autoimmune disease in which
immune cells, predominantly effector T cells, destroy insulin-secreting beta-cells. Beta-cell …

[HTML][HTML] Oral health of children and adolescents with diabetes Mellitus

P Schädlich, J Symmank, A Dost, C Jacobs… - Journal of Clinical …, 2024 - mdpi.com
Aim: To examine the oral health of children and adolescents with and without diabetes
mellitus. Background: Diabetes mellitus is the most common metabolic disease in childhood …

[HTML][HTML] The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus

T Menegucci, EFB Chagas, B de Oliveira Zanuso… - Diseases, 2023 - mdpi.com
Glycated hemoglobin (HbA1c) is used to assess glycemic control in Type 1 diabetes (DM1)
patients. Apolipoproteins play an essential role in DM1 pathophysiology and may be …

Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance

M Apostolopoulou, V Lambadiari, M Roden… - Endocrine …, 2025 - academic.oup.com
People with type 1 diabetes (T1D) are usually considered to exclusively exhibit β-cell failure,
but they frequently also feature insulin resistance. This review discusses the mechanisms …