Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Escherichia coli in Europe: An Overview

N Allocati, M Masulli, MF Alexeyev, C Di Ilio - International journal of …, 2013 - mdpi.com
Escherichia coli remains one of the most frequent causes of several common bacterial
infections in humans and animals. E. coli is the prominent cause of enteritis, urinary tract …

Antimicrobial peptides towards clinical application—A long history to be concluded

L Cresti, G Cappello, A Pini - International Journal of Molecular Sciences, 2024 - mdpi.com
Antimicrobial peptides (AMPs) are molecules with an amphipathic structure that enables
them to interact with bacterial membranes. This interaction can lead to membrane crossing …

Antimicrobial peptides: an overview of a promising class of therapeutics

A Giuliani, G Pirri, S Nicoletto - Open Life Sciences, 2007 - degruyter.com
Antibiotic resistance is increasing at a rate that far exceeds the pace of new development of
drugs. Antimicrobial peptides, both synthetic and from natural sources, have raised interest …

[HTML][HTML] Alpha-helical antimicrobial peptides—Using a sequence template to guide structure–activity relationship studies

I Zelezetsky, A Tossi - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2006 - Elsevier
An important class of cytolytic antimicrobial peptides (AMPs) assumes an amphipathic, α-
helical conformation that permits efficient interaction with biological membranes. Host …

Recent developments in antimicrobial-peptide-conjugated gold nanoparticles

U Rajchakit, V Saro**i - Bioconjugate chemistry, 2017 - ACS Publications
The escalation of multidrug-resistant pathogens has created a dire need to develop novel
ways of addressing this global therapeutic challenge. Because of their antimicrobial …

Nanoparticulate antibiotic systems as antibacterial agents and antibiotic delivery platforms to fight infections

A Vassallo, MF Silletti, I Faraone… - Journal of …, 2020 - Wiley Online Library
Today's human society, product of decades of progress in all fields of knowledge, would
have been unimaginable without the discovery of antibiotics and more generally of …

Designer peptide and protein dendrimers: a cross-sectional analysis

R Sapra, RP Verma, GP Maurya, S Dhawan… - Chemical …, 2019 - ACS Publications
Dendrimers have attracted immense interest in science and technology due to their unique
chemical structure that offers a myriad of opportunities for researchers. Dendritic design …

Challenges and future prospects of antibiotic therapy: from peptides to phages utilization

SM Mandal, A Roy, AK Ghosh, TK Hazra… - Frontiers in …, 2014 - frontiersin.org
Bacterial infections are raising serious concern across the globe. The effectiveness of
conventional antibiotics is decreasing due to global emergence of multi-drug-resistant …

[HTML][HTML] Natural antimicrobial peptides as inspiration for design of a new generation antifungal compounds

M Bondaryk, M Staniszewska, P Zielińska… - Journal of fungi, 2017 - mdpi.com
Invasive fungal infections are associated with high mortality rates, despite appropriate
antifungal therapy. Limited therapeutic options, resistance development and the high …