The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …

Stress is a pervasive component of the human experience. While often considered an
adversity to be ignored, chronic stress has important pathological consequences, including …

Background Over the past 2 decades, the use of intravenous ketamine infusions as a
treatment for chronic pain has increased dramatically, with wide variation in patient …

Mental disorders are rising while development of novel psychiatric medications is declining.
This stall in innovation has also been linked with intense debates on the current diagnostics …

Major depressive disorder (MDD) is severely disabling, and current treatments have limited
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …

Background The symptoms of major depressive disorder (MDD) are rapidly alleviated by
administration of a single dose of the glutamatergic modulator ketamine. However, few …

Depression is a leading cause of disability worldwide and improving its treatment is a core
research priority for future programmes. A change in the view of psychological and …

In this paper, we present the development of the Altered States Database (ASDB), an open-
science project based on a systematic literature review. The ASDB contains psychometric …

Modern psychedelic research and clinical development is at a crucial inflection point, with
great potential for the treatment of many mental illnesses demonstrated but significant …

The subdivisions of the anterior cingulate cortex (ACC)–including subgenual, perigenual
and dorsal zones–are implicated in the etiology, pathogenesis and treatment of major …