Regulation of macrophage cell surface GAPDH alters LL-37 internalization and downstream effects in the cell
Abstract Mycobacterium tuberculosis (M. tb), the major causative agent of tuberculosis, has
evolved mechanisms to evade host defenses and persist within host cells. Host-directed …
evolved mechanisms to evade host defenses and persist within host cells. Host-directed …
[HTML][HTML] Targeting siderophore-mediated iron uptake in M. abscessus: a new strategy to limit the virulence of non-tuberculous mycobacteria
M Mori, G Stelitano, G Cazzaniga, A Gelain, A Tresoldi… - Pharmaceutics, 2023 - mdpi.com
Targeting pathogenic mechanisms, rather than essential processes, represents a very
attractive approach for the development of new antimycobacterial drugs. In this context, iron …
attractive approach for the development of new antimycobacterial drugs. In this context, iron …
Chronic hyperglycemia impairs anti-microbial function of macrophages in response to Mycobacterium tuberculosis infection
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), though the underlying
mechanisms linking DM and TB remain ambiguous. Macrophages are a key player in the …
mechanisms linking DM and TB remain ambiguous. Macrophages are a key player in the …
[HTML][HTML] Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells
Introduction: Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has
emerged as an aggressive viral pandemic. Health care providers confront a challenging task …
emerged as an aggressive viral pandemic. Health care providers confront a challenging task …
Stoichiometry of ligand binding and role of C‐terminal lysines in Mycobacterium tuberculosis and human GAPDH multifunctionality
Glyceraldehyde‐3‐phosphate‐dehydrogenase (GAPDH; EC1. 2.1. 12) has several functions
in Mycobacterium tuberculosis (Mtb) and the human host. Apart from its role in glycolysis, it …
in Mycobacterium tuberculosis (Mtb) and the human host. Apart from its role in glycolysis, it …
Mycobacterium tuberculosis exploits SIRT2 for iron acquisition to facilitate its intracellular survival
Iron availability is a critical factor for both bacteria and humans, and its availability
significantly influences host-pathogen dynamics. As Mtb has coevolved with the human …
significantly influences host-pathogen dynamics. As Mtb has coevolved with the human …