The quantum nature of electrons and nuclei is manifested in countless biological events
including the rearrangements of electrons in biochemical reactions, electron and proton …

Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …

Intrinsically disordered proteins (IDPs) lack stable tertiary and/or secondary structures under
physiological conditions in vitro. They are highly abundant in nature and their functional …

Copper is a trace element, important for the function of many cellular enzymes. Copper ions
can adopt distinct redox states oxidized Cu (II) or reduced (I), allowing the metal to play a …

Recent reports give strong support to the idea that amyloid fibril formation and the
subsequent development of protein deposition diseases originate from conformational …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

There is now direct evidence that copper is bound to amyloid-β peptide (Aβ) in senile plaque
of Alzheimer's disease. Copper is also linked with the neurotoxicity of Aβ and free radical …

The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other
neurodegenerative synucleinopathies. Interactions with metal ions affect dramatically the …

The dominant view in protein science is that a three-dimensional 3-D) structure is a
prerequisite for protein function. In contrast to this dominant view, there are many …

The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other
neurodegenerative synucleinopathies. We demonstrate here that Cu (II) ions are effective in …