Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Background Early immunotherapy administration improves outcomes in patients with N-
methyl-D-aspartate receptor (NMDAR)-antibody encephalitis. As most patients with NMDAR …

This paper outlines a hierarchical Bayesian framework for interoception,
homeostatic/allostatic control, and meta-cognition that connects fatigue and depression to …

Importance Clinical research has shown that persistent negative beliefs maintain depression
and that subanesthetic ketamine infusions induce rapid antidepressant responses. Objective …

Psychotic experiences may be understood as altered information processing due to aberrant
neural computations. A prominent example of such neural computations is the computation …

Dysfunctional decision-making has been implicated in the positive and negative symptoms
of schizophrenia. Decision-making can be conceptualized within the framework of …

Symptom expression in psychiatric conditions is often linked to altered threat perception,
however how computational mechanisms that support aversive learning relate to specific …

The ability to represent and respond to uncertainty is fundamental to human cognition and
decision-making. Noradrenaline (NA) is hypothesized to play a key role in coordinating the …

A comprehensive understanding of psychosis requires models that link multiple levels of
explanation: the neurobiological, the cognitive, the subjective, and the social. Until we can …

The dopaminergic system is firmly implicated in reversal learning but human measurements
of dopamine release as a correlate of reversal learning success are lacking. Dopamine …