Biology of Vascular Endothelial Growth Factor | Endocrine Reviews | Oxford Academic Skip to
Main Content Advertisement Oxford Academic Journals Books Search Menu Information …

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …

The transcriptional response to lowered oxygen levels is mediated by the hypoxia‐inducible
transcription factor (HIF‐1), a heterodimer consisting of the constitutively expressed aryl …

The vascular beds supplying the retina may sustain injury as a result of underlying disease
such as diabetes, and/or the interaction of genetic predisposition, environmental insults, and …

Retinopathy of prematurity (ROP) is initiated by hyperoxia–induced obliteration of newly
formed blood vessels in the retina of the premature newborn. We propose that vessel …

Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision
loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic …

Background It is known that choroidal neovascularization (CNV) in age-related macular
degeneration (ARMD) may erode through the retinal pigment epithelium, infiltrate the …

Features that distinguish tumor vasculatures from normal blood vessels are sought to enable
the destruction of preformed tumor vessels. We show that blood vessels in both a …

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) was originally
discovered in the late 1970s because of its capacity to increase the permeability of …

The blood–retinal barrier (BRB) plays an important role in the homeostatic regulation of the
microenvironment in the retina. It consists of inner and outer components, the inner BRB …