The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

Cancer vaccines are designed to promote tumor specific immune responses, particularly
cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines …

Alpha-fetoprotein (AFP) is a glycoprotein that plays an important role in immune regulation
with critical involvement in early human development and maintaining the immune balance …

Studies of the administration of interleukin-2 to patients with metastatic melanoma or kidney
cancer have shown that immunological manipulations can mediate the durable regression …

Abstract α-Fetoprotein (AFP) is a self protein expressed by fetal liver at high levels, but is
transcriptionally repressed at birth. AFP is up-regulated in hepatocellular carcinomas, and …

Hepatocarcinoma is one of the most prevalent gastroenterological cancers in the world with
less effective therapy. As an oncofetal antigen and diagnostic marker for liver cancer, alpha …

The liver is the largest organ in the body and is generally regarded by non-immunologists as
not having lymphoid function. However, such is far from accurate. This review highlights the …

Purpose: An existing immunological paradigm is that high concentrations of soluble protein
contribute to the maintenance of peripheral tolerance/ignorance to self protein. We tested …

The technological advances occurred in the last few years have led to a great increase in
the number of tumor associated antigens (TAA) that are currently available for clinical …

Simple Summary Hepatocellular carcinoma (HCC) is the most common liver malignancy
associated with poor prognosis. Treatment options are limited partially due to resistance to …