The plasminogen activator (PA) system is an extracellular proteolytic enzyme system
associated with various physiological and pathophysiological processes. A large body of …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic
cancer tissues and can both promote and restrain disease progression. Here, we interrogate …

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between
tumor cells and the stroma to promote tumor progression. Consequently, strategies to target …

Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide and is
predicted to become second in 2030 in industrialized countries if no therapeutic progress is …

In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

Pancreatic ductal adenocarcinoma (PDAC) is a hostile solid malignancy coupled with an
extremely high mortality rate. Metastatic disease is already found in most patients at the time …

Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …

Tumour metastasis is a dynamic and systemic process. It is no longer seen as a tumour cell-
autonomous program but as a multifaceted and complex series of events, which is …

Pancreatic cancer is a highly aggressive malignancy that features high recurrence rates and
the poorest prognosis of all solid cancers. The urokinase plasminogen activation system …