Writing, erasing and reading histone lysine methylations
Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …
many cellular events. Lysine methylations mark various sites on the tail and globular …
The diverse functions of histone lysine methylation
C Martin, Y Zhang - Nature reviews Molecular cell biology, 2005 - nature.com
Covalent modifications of histone tails have fundamental roles in chromatin structure and
function. One such modification, lysine methylation, has important functions in many …
function. One such modification, lysine methylation, has important functions in many …
Role of histone H2A ubiquitination in Polycomb silencing
Covalent modification of histones is important in regulating chromatin dynamics and
transcription,. One example of such modification is ubiquitination, which mainly occurs on …
transcription,. One example of such modification is ubiquitination, which mainly occurs on …
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
Histone and chromatin cross-talk
W Fischle, Y Wang, CD Allis - Current opinion in cell biology, 2003 - Elsevier
Chromatin is the physiologically relevant substrate for all genetic processes inside the nuclei
of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are …
of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are …
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression
A Shilatifard - Annu. Rev. Biochem., 2006 - annualreviews.org
It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …
one cell generation to the next. It has been demonstrated during the past decade that the …
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity
Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation
machinery to a highly localized domain at the 5′ portion of active mRNA coding regions …
machinery to a highly localized domain at the 5′ portion of active mRNA coding regions …
[HTML][HTML] Cellular memory and the histone code
BM Turner - Cell, 2002 - cell.com
The histone tails on the nucleosome surface are subject to enzyme-catalyzed modifications
that may, singly or in combination, form a code specifying patterns of gene expression …
that may, singly or in combination, form a code specifying patterns of gene expression …
[HTML][HTML] Histone ubiquitination: an integrative signaling platform in genome stability
F Mattiroli, L Penengo - Trends in Genetics, 2021 - cell.com
Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
Histones: annotating chromatin
Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …
structured and maneuvered to elicit cellular processes, including transcription, cell division …