Development of an epigenetic clock resistant to changes in immune cell composition
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …
methylation values to predict chronological or biological age. Increases in predicted …
Targeting nuclear hormone receptors for the prevention of breast cancer
CL Moyer, PH Brown - Frontiers in Medicine, 2023 - frontiersin.org
Advancements in research have led to the steady decline of breast cancer mortality over the
past thirty years. However, breast cancer incidence has continued to rise, resulting in an …
past thirty years. However, breast cancer incidence has continued to rise, resulting in an …
Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses
The druggable proteome refers to proteins that can bind to small molecules with appropriate
chemical affinity, inducing a favorable clinical response. Predicting druggable proteins …
chemical affinity, inducing a favorable clinical response. Predicting druggable proteins …
Development of a novel epigenetic clock resistant to changes in immune cell composition
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …
methylation values to predict chronological or biological age. Increases in predicted …
Genomes and epigenomes of matched normal and tumor breast tissue reveal diverse evolutionary trajectories and tumor-host interactions
Normal tissues adjacent to the tumor (NATs) may harbor early breast carcinogenesis events
driven by field cancerization. Although previous studies have characterized copy-number …
driven by field cancerization. Although previous studies have characterized copy-number …
DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment
To individualise breast cancer (BC) prevention, markers to follow a person's changing
environment and health extending beyond static genetic risk scores are required. Here, we …
environment and health extending beyond static genetic risk scores are required. Here, we …
Breast Cancer Risk Reduction: Current Status and Emerging Trends to Increase Efficacy and Reduce Toxicity of Preventive Medication
SA Khan - Surgical Oncology Clinics, 2023 - surgonc.theclinics.com
Although “chemoprevention” is a revered term. it is time for the word to be retired from the
clinic for it conveys the wrong message, that of toxic chemotherapy. The terminology needs …
clinic for it conveys the wrong message, that of toxic chemotherapy. The terminology needs …
Impact of breast cancer and germline BRCA pathogenic variants on fertility preservation in young women
E Prokurotaite, M Condorelli, J Dechene, J Bouziotis… - Life, 2023 - mdpi.com
Background: Several studies have suggested that breast cancer (BC) and germline BRCA
pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve …
pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve …
Antiprogestins for breast cancer treatment: We are almost ready
A Elia, G Pataccini, L Saldain, L Ambrosio… - The Journal of Steroid …, 2024 - Elsevier
The development of antiprogestins was initially a gynecological purpose. However, since
mifepristone was developed, its application for breast cancer treatment was immediately …
mifepristone was developed, its application for breast cancer treatment was immediately …
[HTML][HTML] Secondary Transcriptomic Analysis of Triple-Negative Breast Cancer Reveals Reliable Universal and Subtype-Specific Mechanistic Markers
Simple Summary Breast cancer is diagnosed in 2.3 million women each year and kills
685,000 (~ 30% of patients) worldwide. The most dangerous breast cancer is triple-negative …
685,000 (~ 30% of patients) worldwide. The most dangerous breast cancer is triple-negative …