T cells are critical for protective immune responses to pathogens and tumors. The T-cell
receptor (TCR)–CD3 complex is composed of a diverse αβ TCR heterodimer noncovalently …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …

T cells are triggered when the T-cell receptor (TCR) encounters its antigenic ligand, the
peptide-major histocompatibility complex (pMHC), on the surface of antigen presenting cells …

The immune response is orchestrated by a variety of immune cells. The function of each cell
is determined by the collective signals from various immunoreceptors, whose expression …

A high diversity of αβ T cell receptors (TCRs), capable of recognizing virtually any pathogen
but also self-antigens, is generated during T cell development in the thymus. Nevertheless, a …

T lymphocytes use surface α β T-cell receptors (TCRs) to recognize peptides bound to MHC
molecules (pMHCs) on antigen-presenting cells (APCs). How the exquisite specificity of high …

T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

TCRs recognize cognate pMHCs to initiate T cell signaling and adaptive immunity.
Mechanical force strengthens TCR-pMHC interactions to elicit agonist-specific catch bonds …

The diagnosis of leukemic T-cell malignancies is often challenging, due to overlap**
features with reactive T-cells and limitations of currently available T-cell clonality assays …