It is well-established that testicular spermatozoa are immature and acquire motility and
fertilization capabilities during transit throughout the epididymis. The epididymis is a duct …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Obesity, defined as excessive accumulation of fat in adipose tissue, is a metabolic disorder
resulting from behavioral, environmental and heritable causes. Obesity increases the risks of …

BACKGROUND Knowledge of the proteomic composition of the gametes is essential to
understand reproductive functions. Most of the sperm proteins are related to …

In 1998, Dr David Barker pioneered the novel idea that common chronic diseases result not
only from bad genes and an unhealthy lifestyle, but also from alterations in the intrauterine …

Abstract The Developmental Origins of Health and Disease (DOHaD) paradigm is one of the
most rapidly expanding areas of biomedical research. Environmental stressors that can …

Many parts of the animal body harbor microbial communities, known as animal-associated
microbiomes, that affect the regulation of physiological functions. Studies in human and …

In the last two decades, evidence from human and animal studies suggests that paternal
obesity around the time of conception can have adverse effects on offspring health through …

There is growing evidence that the preconceptual lifestyle and other environmental
exposures of a father can significantly alter the physiological and behavioral phenotypes of …

Purpose Despite accumulating evidence from experimental animal studies showing that
paternal environmental exposures induce genetic and epigenetic alterations in sperm which …