The formation and maintenance of renal cell carcinomas (RCC) involve many cell types,
such as cancer stem and differentiated cells, endothelial cells, fibroblasts and immune cells …

Oncogenic multidrug resistance (MDR) is a multifactorial phenotype intimately linked to
deregulated expression of detoxification transporters. Drug efflux transporters, particularly …

Colorectal cancer (CRC) mortality has diminished for decades due to new and improved
treatment profiles. However, CRC still ranks as the third most diagnosed cancer in the US …

Non–small‐cell lung cancer (NSCLC) appears to be a significant threat to public health
worldwide. MicroRNAs have been identified as significant regulators for the development of …

Background Triple-negative breast cancer (TNBC) development may be associated with
tumor immune escape. This study explores whether the CHI3L1/MAF/CTLA4/S100A4 axis …

Purpose Aberrant expression and activity of histone deacetylases (HDACs) sustain
glioblastoma (GBM) onset and progression, and, therefore, HDAC inhibitors (HDACi) …

Relative to several other p21-activated kinase (PAK) family members, the role of PAK3 in
regulating cancer cell functions remains unclear. Our study obtained evidence that PAK3 …

Gliomas are a heterogeneous group of tumors with evolving classification based on
genotype. Isocitrate dehydrogenase (IDH) mutation is an early event in the formation of …

The presence of cancer stem cells (CSCs) is a major cause of therapeutic failure in a variety
of cancer types, including colorectal cancer (CRC). However, the underlying mechanisms …

Despite advances in chemotherapies that improve cancer survival, most patients who
relapse succumb to the disease due to the presence of cancer stem cells (CSCs), which are …