Dendritic cells: unique leukocyte populations which control the primary immune response
DNJ Hart - Blood, The Journal of the American Society of …, 1997 - ashpublications.org
It is now possible to grow DC-like cells in culture17-21 and extensive cell membrane
processes that are acquired late the first monoclonal antibodies (MoAbs) 22, 23 that react …
processes that are acquired late the first monoclonal antibodies (MoAbs) 22, 23 that react …
Zoned out: functional map** of stromal signaling microenvironments in the thymus
All hematopoietic cells, including T lymphocytes, originate from stem cells that reside in the
bone marrow. Most hematopoietic lineages also mature in the bone marrow, but in this …
bone marrow. Most hematopoietic lineages also mature in the bone marrow, but in this …
Immune regulation by CD40 and its ligand GP39
TM Foy, A Aruffo, J Bajorath… - Annual review of …, 1996 - annualreviews.org
▪ Abstract Over the past three years, CD40 and its ligand (gp39, CD40L, TBAM) have been
shown to be essential for humoral immune responses to thymus-dependent antigens …
shown to be essential for humoral immune responses to thymus-dependent antigens …
Development and selection of T cells: facts and puzzles
P Kisielow, H Von Boehmer - Advances in immunology, 1995 - Elsevier
Mature T cells are essential components of the immune system. They represent
phenotypically and functionally heterogenous populations of lymphocytes that are equipped …
phenotypically and functionally heterogenous populations of lymphocytes that are equipped …
HIV induces thymus depletion in vivo
ML Bonyhadi, L Rabin, S Salimi, DA Brown, J Kosek… - Nature, 1993 - nature.com
HUMAN immunodeficiency virus (HIV) disease is typified by declining CD4+ T lymphocyte
counts in the peripheral circulation, a loss which may be secondary to accelerated …
counts in the peripheral circulation, a loss which may be secondary to accelerated …
Negative selection of CD4+ CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.
CD4+ CD8+ thymocytes expressing self-reactive T cell antigen receptors (TCR) are deleted
in the thymus as a consequence of TCR/self-antigen/major histocompatibility complex …
in the thymus as a consequence of TCR/self-antigen/major histocompatibility complex …
RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation
JJ Priatel, SJ Teh, NA Dower, JC Stone, HS Teh - Immunity, 2002 - cell.com
Two important Ras-guanyl nucleotide exchange factors, Sos and RasGRP1, control Ras
activation in thymocytes. However, the relative contribution of these two exchange factors to …
activation in thymocytes. However, the relative contribution of these two exchange factors to …
Lymphocytes in the peritoneum home to the omentum and are activated by resident dendritic cells
DA Carlow, MR Gold, HJ Ziltener - The Journal of Immunology, 2009 - journals.aai.org
The omentum is of interest in the context of obesity-related metabolic disease where
adipose tissue exhibits inflammatory changes; however, the immunology of the omentum is …
adipose tissue exhibits inflammatory changes; however, the immunology of the omentum is …
An essential role for gp39, the ligand for CD40, in thymic selection.
TM Foy, DM Page, TJ Waldschmidt… - The Journal of …, 1995 - rupress.org
The interactions between CD40 on B cells and its ligand gp39 on activated T helper cells
are known to be essential for the development of thymus-dependent humoral immunity …
are known to be essential for the development of thymus-dependent humoral immunity …
Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) ζ subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR ζ
NSC Van Oers, W Tao, JD Watts… - … and cellular biology, 1993 - Taylor & Francis
The T-cell receptor (TCR) ζ subunit is an important component of the TCR complex, involved
in signal transduction events following TCR engagement. In this study, we showed that the …
in signal transduction events following TCR engagement. In this study, we showed that the …