Butyrylcholinesterase (BChE) is present in plasma and numerous cells and organs. Its
physiological function (s) is (are) still unclear. However, this enzyme is of pharmacological …

Organophosphorus (OP) nerve agents and pesticides present significant threats to civilian
and military populations. OP compounds include the nefarious G and V chemical nerve …

It is tacitly assumed that the biological role of acetylcholinesterase is termination of synaptic
transmission at cholinergic synapses. However, together with its structural homolog …

Recent improvements in direct electron detectors, microscope technology and software
provided the stimulus for aquantum leap'in the application of cryo-electron microscopy in …

The functional structure of proteins results from marginally stable folded conformations.
Reversible unfolding, irreversible denaturation, and deterioration can be caused by …

Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by
progressive memory loss, declining language skills and other cognitive disorders. AD has …

Protection from the toxicity of nerve agents is achieved by pretreatment with human
butyrylcholinesterase (BChE). Current methods for purifying large quantities of BChE from …

Acetylcholinesterase and butyrylcholinesterase (BChE) typically hydrolyze the
neurotransmitter acetylcholine. The multifunctional enzyme BChE is associated with lipid …

Human butyrylcholinesterase (BChE) is an efficient bioscavenger of toxicants. Highly
purified BChE was labelled with the near infrared fluorescent IRDye800CW. The goal was to …

Cholinesterases (ChEs) display a non-michaelian behavior with positively charged
substrates. In the steady-state rate equation, the b factor describes this behavior: if b> 1 …