Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein
p53 (TP53) are missense mutations,. Mutant p53 protein is often abundantly expressed in …

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Abstract'Cellular senescence', a term originally defining the characteristics of cultured cells
that exceed their replicative limit, has been broadened to describe durable states of …

Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …

Malignant mesothelioma is a universally lethal cancer that is increasing in incidence
worldwide. There is a dearth of effective therapies, with only one treatment (pemetrexed and …