Quantitative susceptibility map** as an imaging biomarker for Alzheimer's disease: The expectations and limitations

Y Uchida, H Kan, K Sakurai, K Oishi… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia and a distressing diagnosis
for individuals and caregivers. Researchers and clinical trials have mainly focused on β …

[HTML][HTML] hMRI–A toolbox for quantitative MRI in neuroscience and clinical research

K Tabelow, E Balteau, J Ashburner, MF Callaghan… - Neuroimage, 2019 - Elsevier
Neuroscience and clinical researchers are increasingly interested in quantitative magnetic
resonance imaging (qMRI) due to its sensitivity to micro-structural properties of brain tissue …

Relationship between cortical iron and tau aggregation in Alzheimer's disease

N Spotorno, J Acosta-Cabronero, E Stomrud… - Brain, 2020 - academic.oup.com
A growing body of evidence suggests that the dysregulation of neuronal iron may play a
critical role in Alzheimer's disease. Recent MRI studies have established a relationship …

Brain iron deposition is linked with cognitive severity in Parkinson's disease

GEC Thomas, LA Leyland, AE Schrag… - Journal of Neurology …, 2020 - jnnp.bmj.com
Background Dementia is common in Parkinson's disease (PD) but measures that track
cognitive change in PD are lacking. Brain tissue iron accumulates with age and co-localises …

[HTML][HTML] Associations of quantitative susceptibility map** with Alzheimer's disease clinical and imaging markers

PM Cogswell, HJ Wiste, ML Senjem, JL Gunter… - Neuroimage, 2021 - Elsevier
Altered iron metabolism has been hypothesized to be associated with Alzheimer's disease
pathology, and prior work has shown associations between iron load and beta amyloid …

Sequence of clinical and neurodegeneration events in Parkinson's disease progression

NP Oxtoby, LA Leyland, LM Aksman, GEC Thomas… - Brain, 2021 - academic.oup.com
Dementia is one of the most debilitating aspects of Parkinson's disease. There are no
validated biomarkers that can track Parkinson's disease progression, nor accurately identify …

Regional brain iron and gene expression provide insights into neurodegeneration in Parkinson's disease

GEC Thomas, A Zarkali, M Ryten, K Shmueli… - Brain, 2021 - academic.oup.com
The mechanisms responsible for the selective vulnerability of specific neuronal populations
in Parkinson's disease are poorly understood. Oxidative stress secondary to brain iron …

Neurological update: neuroimaging in dementia

T Rittman - Journal of Neurology, 2020 - Springer
Neuroimaging for dementia has made remarkable progress in recent years, shedding light
on diagnostic subtypes of dementia, predicting prognosis and monitoring pathology. This …

QSM reconstruction challenge 2.0: design and report of results

QSM Challenge 2.0 Organization … - Magnetic …, 2021 - Wiley Online Library
Purpose The aim of the second quantitative susceptibility map** (QSM) reconstruction
challenge (Oct 2019, Seoul, Korea) was to test the accuracy of QSM dipole inversion …

[HTML][HTML] Multi-site harmonization of 7 tesla MRI neuroimaging protocols

WT Clarke, O Mougin, ID Driver, C Rua, AT Morgan… - Neuroimage, 2020 - Elsevier
Increasing numbers of 7 T (7 T) magnetic resonance imaging (MRI) scanners are in
research and clinical use. 7 T MRI can increase the scanning speed, spatial resolution and …