Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …

Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …

Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …

The potential for positron emission tomography (PET) to detect neuroinflammation in vivo
has sparked a remarkable interest in various disciplines of neuroscience. Early PET …

The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …

Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …

[11C] PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron
emission tomography (PET) to detect microglial activation. However, quantitative …

Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …

Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which
no specific treatment has been established yet. Although preclinical models of ICH have …