Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain
cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and …

Phosphodiesterase 4 (PDE4) inhibitors are effective therapeutic agents for various
inflammatory diseases. Roflumilast, apremilast, and crisaborole have been developed and …

Abstract Phosphodiesterase 4 (PDE4) hydrolyzes cyclic adenosine monophosphate (cAMP)
and plays a vital roles in many biological processes. PDE4 inhibitors have been widely …

Phosphodiesterase 4 (PDE4) enzymes catalyze cyclic adenosine monophosphate (cAMP)
hydrolysis and are involved in a variety of physiological processes, including brain function …

Sensorimotor recovery following ischemic stroke is highly related with structural modification
and functional reorganization of residual brain tissues. Manipulations, such as treatment …

Damage of alveolar-capillary barrier, inflammation, oxidative injury, and lung cell apoptosis
represent the key features of acute lung injury (ALI). This study evaluated if selective …

Phosphodiesterases (PDEs) constitute a family of enzymes that play a pivotal role in the
regulation of intracellular levels of cyclic nucleotides, including cyclic adenosine …

Dissolved oxygen (DO) is an essential ecological factor encountered by fish and other
aquatic animals, and hypoxia can adversely affect the physiology, biochemistry and …

The cyclodehydration of O-acylamidoximes at room temperature in the superbase system
KOH/DMSO represents a simple and efficient way to 5-alkenyl-and 5-styryl-1, 2, 4 …

Extensive research into the therapeutics of asthma has yielded numerous effective
interventions over the past few decades. However, adverse effects and ineffectiveness of …