Motile cilia are highly complex hair-like organelles of epithelial cells lining the surface of
various organ systems. Genetic mutations (usually with autosomal recessive inheritance) …

Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

The canonical mitotic cell cycle coordinates DNA replication, centriole duplication and
cytokinesis to generate two cells from one. Some cells, such as mammalian trophoblast …

Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium
and goes on to drive development of most chronic lung diseases. Here, through single cell …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

A finely regulated system of airway epithelial development governs the differentiation of
motile ciliated cells of the human respiratory tract, conferring the body's mucociliary …

Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

Cilia are microtubule-based projections that serve a wide variety of essential functions in
animal cells. Defects in cilia structure or function have recently been found to underlie …

Using a whole-exome sequencing strategy, we identified recessive CCNO (encoding cyclin
O) mutations in 16 individuals suffering from chronic destructive lung disease due to …