Novel therapeutic applications of cardiac glycosides

I Prassas, EP Diamandis - Nature reviews Drug discovery, 2008 - nature.com
Cardiac glycosides are a diverse family of naturally derived compounds that bind to and
inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for …

[HTML][HTML] Cardiac glycosides as novel cancer therapeutic agents

RA Newman, P Yang, AD Pawlus… - Molecular …, 2008 - triggered.stanford.clockss.org
The class of steroid-like compounds designated cardiac glycosides includes well-known
drugs such as digoxin, digitoxin, and ouabain. Their continued efficacy in treatment of …

Anthocyanin‐and hydrolyzable tannin‐rich pomegranate fruit extract modulates MAPK and NF‐κB pathways and inhibits skin tumorigenesis in CD‐1 mice

F Afaq, M Saleem, CG Krueger… - … journal of cancer, 2005 - Wiley Online Library
Chemoprevention has come of age as an effective cancer control modality; however, the
search for novel agent (s) for the armamentarium of cancer chemoprevention continues. We …

Anticancer steroids: linking natural and semi-synthetic compounds

JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

[HTML][HTML] Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer

VR Yadav, S Prasad, B Sung, R Kannappan… - Toxins, 2010 - mdpi.com
Traditional medicine and diet has served mankind through the ages for prevention and
treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation …

Cardiotonic steroids on the road to anti-cancer therapy

T Mijatovic, E Van Quaquebeke, B Delest… - … et Biophysica Acta (BBA …, 2007 - Elsevier
The sodium pump, Na+/K+-ATPase, could be an important target for the development of anti-
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …

COVID-19 therapeutic potential of natural products

Z Low, R Lani, V Tiong, C Poh, S AbuBakar… - International Journal of …, 2023 - mdpi.com
Despite the fact that coronavirus disease 2019 (COVID-19) treatment and management are
now considerably regulated, severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

[HTML][HTML] Anticancer and antiviral properties of cardiac glycosides: a review to explore the mechanism of actions

D Reddy, R Kumavath, D Barh, V Azevedo, P Ghosh - Molecules, 2020 - mdpi.com
Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent
reports have suggested that CGs also possess anticancer and antiviral activities. The …

[HTML][HTML] Emergence of cardiac glycosides as potential drugs: Current and future scope for cancer therapeutics

R Kumavath, S Paul, H Pavithran, MK Paul, P Ghosh… - Biomolecules, 2021 - mdpi.com
Cardiac glycosides are natural sterols and constitute a group of secondary metabolites
isolated from plants and animals. These cardiotonic agents are well recognized and …

Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways

N Kanwal, A Rasul, G Hussain, H Anwar… - Food and Chemical …, 2020 - Elsevier
Nerium oleander, a member of family Apocynaceae, is commonly known as Kaner in various
countries of Asia and Mediterranean region. This plant has been renowned to possess …