The biological function of the cellular prion protein: an update
The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …
Physiology of the prion protein
Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …
Autism-specific maternal autoantibodies recognize critical proteins in develo** brain
Autism spectrum disorders (ASDs) are neurodevelopmental in origin, affecting an estimated
1 in 88 children in the United States. We previously described ASD-specific maternal …
1 in 88 children in the United States. We previously described ASD-specific maternal …
Anti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder
Circulating 45 and 62 kDa antibodies targeting the cerebellum were previously associated
with Autism Spectrum Disorder (ASD), lower adaptive/cognitive function and aberrant …
with Autism Spectrum Disorder (ASD), lower adaptive/cognitive function and aberrant …
Role of α7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1
The prion protein (PrP C) is a conserved glycosylphosphatidylinositol-anchored cell surface
protein expressed by neurons and other cells. Stress-inducible protein 1 (STI1) binds PrP C …
protein expressed by neurons and other cells. Stress-inducible protein 1 (STI1) binds PrP C …
Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR
Transmissible spongiform encephalopathies are fatal neurodegenerative diseases caused
by the conversion of prion protein (PrPC) into an infectious isoform (PrPSc). How this event …
by the conversion of prion protein (PrPC) into an infectious isoform (PrPSc). How this event …
Maternal autoantibody related autism: mechanisms and pathways
KL Jones, J Van de Water - Molecular psychiatry, 2019 - nature.com
It has been estimated that autism spectrum disorder (ASD) now affects 1 in 59 children in the
United States. Although the cause (s) of ASD remain largely unknown, it is becoming …
United States. Although the cause (s) of ASD remain largely unknown, it is becoming …
Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages
ACC da Fonseca, H Wang, H Fan, X Chen… - Journal of …, 2014 - Elsevier
Factors released by glioma-associated microglia/macrophages (GAMs) play an important
role in the growth and infiltration of tumors. We have previously demonstrated that the co …
role in the growth and infiltration of tumors. We have previously demonstrated that the co …
PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy
Prion protein modulates many cellular functions including the secretion of trophic factors by
astrocytes. Some of these factors are found in exosomes, which are formed within …
astrocytes. Some of these factors are found in exosomes, which are formed within …
Dissecting the copper bioinorganic chemistry of the functional and pathological roles of the prion protein: Relevance in Alzheimer's disease and cancer
The cellular prion protein (PrP C) is a metal-binding biomolecule that can interact with
different protein partners involved in pivotal physiological processes, such as neurogenesis …
different protein partners involved in pivotal physiological processes, such as neurogenesis …