Living organisms have evolved various mechanisms to control their metabolism and
response to various stresses, allowing them to survive and grow in different environments. In …

Tumor cells may adapt to metabolic challenges by alternating between glycolysis and
oxidative phosphorylation (OXPHOS). To target this metabolic plasticity, we combined …

Maintenance of genome integrity is fundamental for cellular physiology. Our hereditary
information encoded in the DNA is intrinsically susceptible to suffer variations, mostly due to …

We report a novel multifunctional construct, M1, designed explicitly to target the DNA
damage response in cancer cells. M1 contains both a floxuridine (FUDR) and protein …

We commenced to analyze putative anti-pyroptosis effects of puerarin (PU) as mediated by
the PP2A-HDAC1-NLRP3 pathway in acute lung injury (ALI). ALI animal and cell models …

Protein phosphatase 2A (PP2A) critically regulates cell signaling and is a human tumor
suppressor. PP2A complexes are modulated by proteins such as cancerous inhibitor of …

A well-functioning placenta is crucial for normal gestation and regulates the nutrient, gas,
and waste exchanges between the maternal and fetal circulations and is an important …

Emerging evidence indicates that HIV-1 hijacks host DNA damage repair (DDR) pathways to
facilitate multiple facets of virus replication. Canonically, HIV-1 engages proviral DDR …

Drug resistance is one major reason for failure of cancer therapy. In the past 10 years,
evidence emerged showing that ceramides of specific chain length, generated by six …

Gastric cancer metastasis associated long noncoding RNA (GMAN), a long noncoding RNA,
is associated with metastasis in gastric cancer. However, its underlying mechanisms in …