The animal trypanosomiases and their chemotherapy: a review

F Giordani, LJ Morrison, TG Rowan, HP De Koning… - Parasitology, 2016 - cambridge.org
Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …

Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Management of trypanosomiasis and leishmaniasis

MP Barrett, SL Croft - British medical bulletin, 2012 - academic.oup.com
Background The current treatments for human African trypanosomiasis (HAT), Chagas
disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from …

New drugs for human African trypanosomiasis: a twenty first century success story

EA Dickie, F Giordani, MK Gould, P Mäser… - Tropical medicine and …, 2020 - mdpi.com
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …

The drugs of slee** sickness: their mechanisms of action and resistance, and a brief history

H P. De Koning - Tropical Medicine and Infectious Disease, 2020 - mdpi.com
With the incidence of slee** sickness in decline and genuine progress being made
towards the WHO goal of eliminating slee** sickness as a major public health concern …

[HTML][HTML] Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

MA Ungogo, HP de Koning - … Journal for Parasitology: Drugs and Drug …, 2024 - Elsevier
Animal trypanosomiasis (AT) is a complex of veterinary diseases known under various
names such as nagana, surra, dourine and mal de caderas, depending on the country, the …

Drug resistance in human African trypanosomiasis

MP Barrett, IM Vincent, RJS Burchmore… - Future …, 2011 - Taylor & Francis
Human African trypanosomiasis or 'slee** sickness 'is a neglected tropical disease
caused by the parasite Trypanosoma brucei. A decade of intense international cooperation …

Development of novel drugs for human African trypanosomiasis

R Brun, R Don, RT Jacobs, MZ Wang… - Future …, 2011 - Taylor & Francis
Human African trypanosomiasis (HAT) or 'slee** sickness 'is a neglected tropical disease
caused by the parasite Trypanosoma brucei. Novel models for funding pharmaceutical …

Novel amidines and analogues as promising agents against intracellular parasites: a systematic review

MNC Soeiro, K Werbovetz, DW Boykin, WD Wilson… - Parasitology, 2013 - cambridge.org
Parasitic protozoa comprise diverse aetiological agents responsible for important diseases
in humans and animals including slee** sickness, Chagas disease, leishmaniasis …

Minor groove binders as anti-infective agents

MP Barrett, CG Gemmell, CJ Suckling - Pharmacology & therapeutics, 2013 - Elsevier
Minor groove binders are small molecules that form strong complexes with the minor groove
of DNA. There are several structural types of which distamycin and netropsin analogues …