• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

During ageing, the secretory patterns of the hormones produced by the hypothalamic–
pituitary axis change, as does the sensitivity of the axis to negative feedback by end …

Abstract The Canadian Cardiovascular Society (CCS) atrial fibrillation (AF) guidelines
program was developed to aid clinicians in the management of these complex patients, as …

Background: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies.
Appropriate treatment requires an accurate diagnosis and is influenced by coexisting …

Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%–26%). The
aim of this article is to review the clinical epidemiological features of AF and to relate them to …

Atrial fibrillation (AF) is a major public health burden worldwide, and its prevalence is set to
increase owing to widespread population ageing, especially in rapidly develo** countries …

Thyroid nodules are detected in up to 50 to 60% of healthy subjects. Most nodules do not
cause clinically significant symptoms, and as a result, the main challenge in their …

Atrial fibrillation (AF) is the most common sustained arrhythmia in women and men
worldwide. During the past century, a range of risk factors has been associated with AF …

Surveys and registries are needed to verify that real-life daily practice is in kee** with what
is recommended in the guidelines, thus completing the loop between clinical research …

Endogenous subclinical hyperthyroidism (SHyper) is caused by Graves' disease,
autonomously functioning thyroid nodules and multinodular goitre. Its diagnosis is based on …