Bone fracture repair is a complex, multi-step process that involves communication between
immune and stromal cells to coordinate the repair and regeneration of damaged tissue. In …

The immune system plays a crucial role during tissue repair and wound healing processes.
Biomaterials have been leveraged to assist in this in situ tissue regeneration process to …

Severe traumatic injuries are a widespread and challenging clinical problem, and yet the
factors that drive successful healing and restoration of function are still not well understood …

Bone nonunions arising from large bone defects and composite injuries remain compelling
challenges for orthopedic surgeons. Biological changes associated with nonunions, such as …

Orthopedic biomaterial-associated infections remain a major clinical challenge, with
Staphylococcus aureus being the most common pathogen. S. aureus biofilm formation …

Background Multi-organ dysfunction syndrome and multi-organ failure are the leading
causes of late death in patients sustaining severe blunt trauma. So far, there is no …

Bone non-unions resulting from severe traumatic injuries pose significant clinical
challenges, and the biological factors that drive progression towards and healing from these …

Musculoskeletal disorders are extremely prevalent and a leading cause of chronic pain and
disability. Immunomodulatory cell therapy has potential to improve treatment of …

The primary objective of this thesis was to quantify patient-specific loading and rehabilitation
parameters to elucidate how specific rehabilitation conditions impact bone healing after …

Complex bone injuries often impact several types of tissue and experience healing
complications due to injury severity, infection, instability, or other comorbidities such as …