Targeting disease with benzoxazoles: a comprehensive review of recent developments

A Abdullahi, KY Yeong - Medicinal Chemistry Research, 2024 - Springer
Benzoxazole is an attractive scaffold in medicinal chemistry due to its diverse biological
applications. From 2016 to 2023, a plethora of benzoxazole derivatives have been …

Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR …

AM El-Naggar, AMA Hassan, EB Elkaeed… - Bioorganic …, 2022 - Elsevier
Guided by the pharmacophoric features of both EGFR and VEGFR-2 antagonists, two novel
series of 4-methoxyphenyl pyrazole and pyrimidine derivatives [(4a-c) and (5a-c, 6, 7a-c, 8 …

Novel VEGFR-2 Kinase Inhibitors as Anticancer Agents: A Review Focusing on SAR and Molecular Docking Studies (2016-2021).

K Kajal, S Mondal, SK Wahan, P Patel - Chemistry & Biodiversity, 2023 - europepmc.org
Cancer growth, annexation, and metastatic spread are all aided by the formation of new
blood vessels (angiogenesis). The commencement of the VEGF pathway leads to signal …

Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti …

WAA Fadaly, MTM Nemr, NM Kahk - Bioorganic chemistry, 2024 - Elsevier
A novel series of pyrazole derivatives with urea/thiourea scaffolds 16a-l as hybrid
sorafenib/erlotinib/celecoxib analogs was designed, synthesized and tested for its VEGFR-2 …

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M

AA Nasser, IH Eissa, MR Oun, MA El-Zahabi… - Organic & …, 2020 - pubs.rsc.org
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …

In silico and in vitro studies for benzimidazole anthelmintics repurposing as VEGFR-2 antagonists: novel mebendazole-loaded mixed micelles with enhanced …

AA Elmaaty, KM Darwish, A Chrouda, AA Boseila… - ACS …, 2021 - ACS Publications
Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …

Synthesis, spectroscopic characterization studies of chelating complexes and their applications as antimicrobial agents, DNA binding, molecular docking, and …

MM El‐Zahed, MA Diab, AZ El‐Sonbati… - Applied …, 2024 - Wiley Online Library
N, N′‐bis (2, 4‐dihydroxy benzaldehyde‐1, 2‐diaminobenzene)(H4L) formed from the
reaction of 2, 4‐dihydroxybenzaldehyde and 1, 2‐diaminobenzene was complexed with Cu …

New bis ([1, 2, 4] triazolo)[4, 3-a: 3′, 4′-c] quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer …

MM Alanazi, HA Mahdy, NA Alsaif, AJ Obaidullah… - Bioorganic …, 2021 - Elsevier
A new series of bis ([1, 2, 4] triazolo)[4, 3-a: 3′, 4′-c] quinoxaline derivatives were
designed and synthesized to have the main essential pharmacophoric features of VEGFR-2 …

Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: In silico and in vitro studies

RM El-Masry, AA Al-Karmalawy, R Alnajjar… - New Journal of …, 2022 - pubs.rsc.org
In this study, a series of 1, 3, 4-oxadiazoles carrying the isatin moiety (IVa–g) as anti-SARS-
CoV-2 agents were designed and synthesized. Molecular docking of the compounds (IVa–g) …

Discovery of new quinoxaline-2 (1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation

K El-Adl, HM Sakr, RG Yousef, ABM Mehany… - Bioorganic …, 2021 - Elsevier
VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …