Mitochondrial dysfunction and oxidative stress in Parkinson's disease
SR Subramaniam, MF Chesselet - Progress in neurobiology, 2013 - Elsevier
Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …
Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
DP Narendra, SM **, A Tanaka, DF Suen… - PLoS …, 2010 - journals.plos.org
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and
mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the …
mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the …
Genetic animal models of Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
AW Greene, K Grenier, MA Aguileta, S Muise… - EMBO …, 2012 - embopress.org
Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
Mitochondrial dysregulation is strongly implicated in Parkinson disease. Mutations in PTEN-
induced kinase 1 (PINK1) are associated with familial parkinsonism and neuropsychiatric …
induced kinase 1 (PINK1) are associated with familial parkinsonism and neuropsychiatric …
What genetics tells us about the causes and mechanisms of Parkinson's disease
O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
N Exner, AK Lutz, C Haass, KF Winklhofer - The EMBO journal, 2012 - embopress.org
Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …
biochemical, and physiological features. They are characterized by high rates of metabolic …
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a
neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular …
neurodegenerative disorder of unknown etiology. Parkin has been linked to multiple cellular …
[HTML][HTML] Mitochondrial dysfunction in Parkinson's disease
KF Winklhofer, C Haass - Biochimica et Biophysica Acta (BBA)-Molecular …, 2010 - Elsevier
Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …
their prominent role in energy metabolism, mitochondria are intimately involved in various …