Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …
either promoters or inhibitors of cell death. The functional interplay and balance between the …
Mitochondrial dynamics proteins as emerging drug targets
The importance of mitochondrial dynamics, the physiological process of mitochondrial fusion
and fission, in regulating diverse cellular functions and cellular fitness has been well …
and fission, in regulating diverse cellular functions and cellular fitness has been well …
[HTML][HTML] Mitophagy in the retina: viewing mitochondrial homeostasis through a new lens
Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …
that has one of the highest metabolic rates body-wide and is constantly exposed to …
Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …
Targeting mitochondrial shape: at the heart of cardioprotection
There remains an unmet need to identify novel therapeutic strategies capable of protecting
the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to …
the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to …
Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been
recently linked to a number of inflammatory diseases. Here, we report that the release of mt …
recently linked to a number of inflammatory diseases. Here, we report that the release of mt …
Mitochondrial dynamics and psychiatric disorders: The missing link
Elucidating the molecular mechanisms of psychopathology is crucial for optimized diagnosis
and treatment. Accumulating literature has underlined how mitochondrial bioenergetics …
and treatment. Accumulating literature has underlined how mitochondrial bioenergetics …
Sema3A secreted by sensory nerve induces bone formation under mechanical loads
H Mei, Z Li, Q Lv, X Li, Y Wu, Q Feng, Z Jiang… - International Journal of …, 2024 - nature.com
Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone
remodeling. Here, we focused on the role of Semaphorin 3A (Sema3A), expressed by …
remodeling. Here, we focused on the role of Semaphorin 3A (Sema3A), expressed by …
Metabolic remodeling in cancer and senescence and its therapeutic implications
Cellular metabolism is a flexible and plastic network that often dictates physiological and
pathological states of the cell, including differentiation, cancer, and aging. Recent advances …
pathological states of the cell, including differentiation, cancer, and aging. Recent advances …
DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs
GL Robertson, S Riffle, M Patel… - Journal of cell …, 2023 - journals.biologists.com
Mitochondria and peroxisomes are dynamic signaling organelles that constantly undergo
fission, driven by the large GTPase dynamin-related protein 1 (DRP1; encoded by DNM1L) …
fission, driven by the large GTPase dynamin-related protein 1 (DRP1; encoded by DNM1L) …