RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells
obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely …

Standardized variant curation is essential for clinical care recommendations for patients with
inherited disorders. Clinical Genome Resource (ClinGen) variant curation expert panels are …

The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved
and encode proteins involved in a variety of cell lineages, including blood and blood-related …

Recognition that germline mutations can predispose individuals to blood cancers, often
presenting as secondary leukemias, has largely been driven in the last 20 years by studies …

Abstract Gain of chromosome 21 (Hsa21) is among the most frequent aneuploidies in
leukemia. However, it remains unclear how partial or complete amplifications of Hsa21 …

The model systems available for studying human hematopoiesis, malignant hematopoiesis,
and hematopoietic stem cell (HSC) function in vivo have improved dramatically over the last …

Hemogenic endothelium is a specialized subset of develo** vascular endothelium that
acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and …

Epigenetic control of gene expression programs is essential for normal organismal
development and cellular function. Abrogation of epigenetic regulation is seen in many …