Lipid-based nanoparticles for drug/gene delivery: An overview of the production techniques and difficulties encountered in their industrial development
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery
systems complementing conventional pharmacology has been widely acknowledged …
systems complementing conventional pharmacology has been widely acknowledged …
Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …
Clinical delivery of circular RNA: lessons learned from RNA drug development
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …
which play diverse roles in regulating biological processes and disease states. The …
Solid lipid nanoparticles and nanostructured lipid carriers: A review of the methods of manufacture and routes of administration
The bioavailability of drugs is dependent on several factors such as solubility and the
administration route. A drug with poor aqueous solubility, therefore, poses challenges with …
administration route. A drug with poor aqueous solubility, therefore, poses challenges with …
[HTML][HTML] Small tech, big impact: Agri-nanotechnology journey to optimize crop protection and production for sustainable agriculture
The world's climate shifts rapidly, leading to increasingly severe and volatile weather,
negatively impacting crop yields. To produce long-lasting crops, cutting-edge …
negatively impacting crop yields. To produce long-lasting crops, cutting-edge …
Bioinspired Spatiotemporal Management toward RNA Therapies
Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …
intervention, especially with some that have been approved by the FDA such as the mRNA …
An overview of nanoparticle protein corona literature
The protein corona forms spontaneously on nanoparticle surfaces when nanomaterials are
introduced into any biological system/fluid. Reliable characterization of the protein corona is …
introduced into any biological system/fluid. Reliable characterization of the protein corona is …
Lipid nanoparticles for siRNA delivery in cancer treatment
RNA-based therapies, and siRNAs in particular, have attractive therapeutic potential for
cancer treatment due to their ability to silence genes that are imperative for tumor …
cancer treatment due to their ability to silence genes that are imperative for tumor …
Current advances in lipid nanosystems intended for topical and transdermal drug delivery applications
Skin delivery is an exciting and challenging field. It is a promising approach for effective drug
delivery due to its ease of administration, ease of handling, high flexibility, controlled …
delivery due to its ease of administration, ease of handling, high flexibility, controlled …
Design of experiments in the optimization of nanoparticle-based drug delivery systems
Abstract Design of experiment (DoE) is a powerful statistical technique used for variable
screening and optimization. It is based on the simultaneous variation of multiple factors with …
screening and optimization. It is based on the simultaneous variation of multiple factors with …