Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

A detailed depiction of the'integrin adhesome', consisting of a complex network of 156
components linked together and modified by 690 interactions is presented. Different views of …

Background A number of adhesion-mediated signaling pathways and cell-cycle events have
been identified that regulate cell proliferation, yet studies to date have been unable to …

Diverse cellular processes are carried out by distinct integrin-mediated adhesions. Cell
spreading and migration are driven by focal complexes; robust adhesion to the extracellular …

Adhesion sites, which interconnect cells with their neighbors or with the extracellular matrix
(ECM), are large multiprotein complexes that provide mechanical coupling as well as a …

Recent experiments have shown that spreading epithelial sheets exhibit a long-range
coordination of motility forces that leads to a buildup of tension in the tissue, which may …

Low back pain (LBP) is a chronic condition that can affect up to 80% of the global
population. It is the number one cause of disability worldwide and has enormous …

Adhesion-mediated signaling provides cells with information about multiple parameters of
their microenvironment, including mechanical characteristics. Often, such signaling is based …

The Cas family of multiadaptor and scaffold molecules has an essential role in intracellular
signaling events. Although these proteins do not have enzymatic or transcriptional activity …