Reality CHEK: Understanding the biology and clinical potential of CHK1
F Neizer-Ashun, R Bhattacharya - Cancer letters, 2021 - Elsevier
The DNA damage response enables cells to cope with various stresses that threaten
genomic integrity. A critical component of this response is the serine/threonine kinase CHK1 …
genomic integrity. A critical component of this response is the serine/threonine kinase CHK1 …
Targeting DNA repair pathway in cancer: Mechanisms and clinical application
M Wang, S Chen, D Ao - MedComm, 2021 - Wiley Online Library
Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …
Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure
SUMOylation regulates numerous cellular stress responses, yet targets in the apoptotic
machinery remain elusive. We show that a single, DNA damage-induced monoSUMOylation …
machinery remain elusive. We show that a single, DNA damage-induced monoSUMOylation …
Elucidating the Unknown Biology of the Lysine Rich Coiled-Coil 1 (KRCC1): A Novel Target in Cancer
F Neizer-Ashun - 2022 - search.proquest.com
Relapse and chemo-resistance constitute major impediments to cancer therapy. Over the
years, exhaustive research on a handful of targets has not yielded any major advances, but …
years, exhaustive research on a handful of targets has not yielded any major advances, but …