Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …

One-quarter of photosynthesis-derived carbon on Earth rapidly cycles through a set of short-
lived seawater metabolites that are generated from the activities of marine phytoplankton …

The human gut microbiome plays an important role in resisting colonization of the host by
pathogens, but we lack the ability to predict which communities will be protective. We …

Abstract Late Pliocene and Early Pleistocene epochs 3.6 to 0.8 million years ago had
climates resembling those forecasted under future warming. Palaeoclimatic records show …

Bacteria from the Turicibacter genus are prominent members of the mammalian gut
microbiota and correlate with alterations in dietary fat and body weight, but the specific …

The nature of the last universal common ancestor (LUCA), its age and its impact on the Earth
system have been the subject of vigorous debate across diverse disciplines, often based on …

Gut commensal bacteria with the ability to translocate across the intestinal barrier can drive
the development of diverse immune-mediated diseases,,–. However, the key factors that …

DNA viruses have a major influence on the ecology and evolution of cellular organisms,,–,
but their overall diversity and evolutionary trajectories remain elusive. Here we carried out a …

Nitrogen (N2) fixation in oligotrophic surface waters is the main source of new nitrogen to the
ocean and has a key role in fuelling the biological carbon pump. Oceanic N2 fixation has …

Human skin functions as a physical barrier to foreign pathogen invasion and houses
numerous commensals. Shifts in the human skin microbiome have been associated with …